Complex aluminium compounds
In nature there are numerous compounds of aluminium with alkaline and alkaline-earth metals forming a whole series of basic substances which neutralize acids. Only a few of these substances are suitable, however, for the preparation of antacids. These are compounds which rapidly neutralize gastric acid with no, or only very minor, side effects.
Dihydroxy Aluminium Sodium Carbonate (DASC) A 265
NaAl(OH)2(CO3) x H2O
DASC A 265 is a crystalline, complex basic carbonate of aluminium and sodium. Its rapid neutralization of gastric acid plus its high acid neutralizing capacity make DASC A 265 one of the most effective antacid substances available. The reaction velocity of DASC A 265 remains unaffected by the presence of proteins and pepsin. Bile acids and other aggressors are adsorbed by DASC A 265 preventing damage to the mucous membranes.
| Assay | 98,3 - 107,9% |
| Density (tapped) | 0,4 - 0,6 [g/ml] |
| d50 | 3 - 6 µm |
| Pharmacopoeia | USP |
Aluminium Phosphate
AlPO4 x H2O
Amorphous, tertiary aluminium phosphate exerts its antacid action by building a protective film over the mucous membranes of the digestive system. This protective film prevents acid from reaching the stomach wall and thus creates favourable conditions for the healing of lesions. The astringent and anti-inflammatory action of aluminium phosphate also contributes to the healing of gastrointestinal lesions.
Aluminium phosphate does not alter the pH of the stomach. Hence the natural protection of the stomach and intestinal tract by the germicidal action of gastric acid is undisturbed.
Aluminium Phosphate Powder B 111
B 111 is used in the production of tablets and dry powder formulations which dissolve in the stomach and release colloidal aluminium phosphate.
| Assay | Min. 80% AlPO4 |
| Density | 0,4 - 0,6 [g/ml] |
| d50 | 20 - 35 µm |
| Pharmacopoeia | USP |
Aluminium Phosphate Suspension B 210
B 210 is a white, viscous suspension of amorphous, tertiary aluminium phosphate, which due to its colloidal structure, is highly efficient in liquid preparations. The use of B210 optimizes not only the formation of the protective film in the stomach, but also the adsorption of mucous membrane aggressors and gastric acid, thus facilitating the healing process.
| Assay | 19 - 25% AlPO4 |
| Viscosity (Brookfield) | max. 1000 mPa s (LV 2/60) |
| Pharmacopoeia | USP, Ph.Eur. |
Magnesium Aluminium Silicate Hydrate ( Almasilate Types )
AlxMgy(OH)z(SiO2)(3x+2y-z) · x H2O *)
Magnesium aluminium silicate hydrates are basic amorphous compounds prepared by co-precipitation. The acid binding capacity of the silicate hydrates increases with decreasing silicate content. The presence of the silicate fraction, which is insoluble in acid, not only facilitates the formation of a protective film on the mucous membranes, but also adsorbs mucous membrane aggressors such as pepsin and bile acids.
*) The ratio of the components, Al, Mg, Si can be adjusted to meet individual requirements.
Almasilate Powder C 212 / Almasilate Suspension C 612
Al3Mg5(OH)15(SiO2)2 · x H2O
Almasilate types C 212 and C 612 are our standard grades of aluminium magnesium hydroxysilicate. They have a rapid reaction velocity and high acid neutralizing capacity compared to other silicates. Almasilate type C 212 is a fine powder used in the production of tablets and Almasilate type C 612 is a pumpable suspension suitable for liquid antacid formulations.
| Type | C 212 | C 612 |
| Assay Al2O3 | 15-25 [%] | min. 2,3 [%] |
| Assay MgO | 25-35 [%] | min. 3,5 [%] |
| Density (tapped) | 0,25-0,35 [g/ml] | - |
| d50 | 25-40 µm | - |
| Viscosity (Brookfield) | - | < 104 mPa s (LV 3/12) |